Location: I-220 and US 80, Jackson Immediately after US 80 we’ll approach I-20. Location: I-220 and I-20, Jackson Exit right for I-20 west to Vicksburg. Keep left for I-20 east and US 49 south towards Meridian and Hattiesburg. I-220 ends.  S to I-55/US-51, N to I-220  N to US-49  E to I-55/US-51, W to MS-18 … Continue reading U.S. Route 49, US-80 to I-20/I-220